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MSB Seminar Talk: Post-Mitotic Assembly of the Nuclear Pore Complex in Hutchinson-Gilford Progeria

Speaker: Jennifer Röhrl - Doctoral student in the research group "Epigenetics of Skin Aging" led by Prof. Karima Djabali

Time: 26 November 2019, 1:00 pm

Place: Munich School of BioEngineering (Lecture Hall E.126, Boltzmannstr. 11, 85748 Garching)

Abstract: Hutchinson Gilford progeria (HGPS) is a rare premature aging disease, with patients having an average lifespan of 14.7 years. The disease is caused by a mutation in the LMNA gene, which disrupts the stability of the nuclear envelope. The mutant protein is called progerin and it not only causes abnormalities in the shape of the nucleus, but also affects the distribution of important Nuclear Components. One of the affected protein complexes, is the Nuclear Pore Complex, the gateway between the nucleus and the cytoplasm. In this talk, I will focus on the mechanism(s), by which progerin disturbs Nuclear Pores.