, Events

MIBE Seminar: Preoptic Area and Dorsal Habenula Jointly Support Homeostatic Navigation in Larval Zebrafish

Titel: Preoptic Area and Dorsal Habenula Jointly Support Homeostatic Navigation in Larval Zebrafish

Sprecherin: Virginia Palieri, Doctoral Candidate (Portugues Group)

Datum und Uhrzeit:  Dienstag, 25. April 2023, 13:00

Abstract: To prevent damage, animals must maintain physiological processes within an optimal range, despite environmental perturbations. One prime example is thermoregulation. Homeotherms like mammals and birds can couple autonomic measures like shivering/sweating with behavioral strategies. On the contrary, ectotherms, such as fish, amphibians, reptiles and the vast majority of invertebrates need to move, to navigate toward places where the external temperature matches their homeostatic setpoint (i.e. homeostatic navigation). We investigated the importance of sensory history and previous motor choices in shaping structured, coherent trajectories essential for preventing thermal stress in small ectotherms, like larval zebrafish, when they are pushed away from their homeostatic setpoint. We employed whole-brain functional imaging, targeted chemogenetic and laser ablations in larval zebrafish to show that evolutionarily conserved pathways have been repurposed in a species-specific manner to drive different aspects of homeostatic navigation.
On one hand, the Preoptic Area (PoA), a part of the hypothalamus, involved in controlling core body temperature in mammals, acts like a thermostat switching the fish behavioral strategy in a non-directional manner integrating the immediate sensory evidence. The Habenula-Interpeduncular nucleus-Raphe circuit, on the other hand, supports the PoA by storing a longer memory of the stimulus changes and driving coherent trajectories. 

WEITERE INFORMATIONEN

Das MIBE Seminar findet in Präsenz im Hörsaal E.126 (Boltzmannstraße 11, 85748 Garching) statt und wird zusätzlich live per zoom übertragen.

Zoom Daten für alle online Seminarvorträge in diesem Semester:

Meeting Name: MIBE Seminar Talks, Tuesdays 1:00 pm
https://tum-conf.zoom.us/j/69851298624?pwd=TURFMGQ5N3pDZ0ZGVkVHejFTMFJhUT09
Meeting-ID: 698 5129 8624
Password: mibe

Das MIBE Seminar kann für Promovierende als fachliche Qualifizierung angerechnet werden.
Registrierung hier.

 

WEITERE TERMINE IM SOMMERSEMESTER 2023

02 May 2023 1:00 pm Samuel Randriamanantsoa Doct. Cand.
(Bausch Group)
tbd
09 May 2023 1:00 pm Sinem Sürmeli Doct. Cand.
(Grünewald Group)
Developing CRISPR Medicines for Heart Disease.
16 May 2023 1:00 pm N.N. Doct. Cand.
(Mela/Lieleg)
tbd
23 May 2023 1:00 pm N.N. Doct. Cand.
(Mela/Lieleg)
tbd
06 June 2023 1:00 pm N.N. Doct. Cand.
(Mela/Lieleg)
tbd
13 June 2023 1:00 pm N.N. Doct. Cand.
(Mela/Lieleg)
tbd
20 June 2023 1:00 pm N.N. Doct. Cand.
(Grünewald/Moretti)
tbd
27 June 2023 1:00 pm N.N. Doct. Cand.
(Grünewald/Moretti)
tbd
04 July 2023 1:00 pm N.N. Doct. Cand.
(Grünewald/Moretti)
tbd
11 July 2023 1:00 pm N.N. Doct. Cand.
(Grünewald/Moretti)
tbd