Titel: Combination Treatment of Hutchinson Gilford Progeria Syndrome
Sprecher: Elena Vehns, Djabali Group
Datum und Uhrzeit: Dienstag, 20. Juli 2021, 13:00 Uhr
Abstract: Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare premature aging disease. Worldwide approximately 20 million people are affected from this disease. This syndrome is caused by a mutation in the LMNA gene, resulting in a permanently farnesylated and carboxymethylated protein called progerin. HGPS patients develop several features of physiological aging including arthritis and atherosclerosis. Since there is no cure for this disease, we are working on a novel therapeutic treatment option for HGPS. Therefore, we combined two drugs with different modes of action to find out whether they had a synergistic effect.
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