Titel: In vivo pH-imaging using hyper polarized zymonic acid as for the characterization of healthy tissue and tumor metabolism
Datum und Uhrzeit: Dienstag, 04. August, 13:00 Uhr
Sprecher: Martin Grashei, Schilling Group
Hyperpolarization of nuclei is a method to enhance the sensitivity of NMR-active nuclei by several orders of magnitude. Hyperpolarized 13C-labelled biomolecules bear the potential to non-invasively characterize a variety of metabolic parameters such as enzymatic activity or pH using magnetic resonance spectroscopic imaging. In our group, we used the deuterated and 13C-labeled pH-sensor [1,5-13C2, 3,6,6,6-D4]zymonic acid, which is polarized using dynamic nuclear polarization, for acquisition of spatially resolved information on the tissue pH, thereby allowing in vivo pH imaging. We further applied this technique to characterize renal function of mice and metabolism of tumors. Our aim is to evaluate the potential of pH-imaging as a tool to diagnose different pathologies, especially for assessment of tumor prognosis and therapy response.