MSB Online Seminar: Mucin-based nanoparticles for DNA-guided intracellular drug delivery

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Titel: Mucin-based nanoparticles for DNA-guided intracellular drug delivery 

Datum und Uhrzeit: Dienstag, 10. November 2020, 13:00 Uhr

Sprecherin: Ceren Kimna, Arbeitsgruppe „Biopoloymere und Bio-Grenzflächen” (Prof. Oliver Lieleg)

Abstract:

The targeted intracellular delivery of therapeutics to a specific disease site is still very challenging. Especially when drugs such as chemotherapeutics are used, the importance of a control mechanism that differentiates the target cells from the off-target, healthy tissue is indisputable. In this study, we designed mucin-based nanocarriers which can undergo a conformational change upon request to deliver active agents. With this strategy, we can accumulate the drug molecules in the cytosol and initiate their liberation in presence of a trigger DNA sequence. Furthermore, we demonstrate, how an endogenous marker, e.g., specific miRNA overexpression, can be used as a stimulus to autonomously initiate the intracellular drug release. We expect that this highly specific delivery mechanism can pave the way for the design of patient-tailored treatments for such diseases, where overexpression of signature oligonucleotide sequences has been identified. Original Article: https://pubs.acs.org/doi/10.1021/acsnano.0c04035 
 

Weitere Informationen

Das MSB-Seminar wird in diesem Semester online (Zoom) stattfinden. Wenn Sie an dem Vortrag interessiert sind, können Sie sich per Email (julia.knuerr(at)tum.de) anmelden. Die Zugangsdaten werden Ihnen dann zugeschickt.
 

Programm Wintersemester 2020/2021

17. November 2020 13:00 Uhr tbd tbd tbd
24. November 2020 13:00 Uhr Jose Page Lasser Group tbd
1. Dezember 2020 13:00 Uhr Franciso Zurita Wolfrum Group Peripheral nerve modulation for tissue control 
8. Dezember 2020 13:00 Uhr tbd tbd tbd
15. Dezember 2020 13:00 Uhr tbd tbd tbd
12. Januar 2021 13:00 Uhr Bojan Sandurkov Gleich Group tbd
19. Januar 2021 13:00 Uhr Albert Cronert Hemmert Group tbd
26. Januar 2021 13:00 Uhr Klaus Wagenbauer Dietz Group tbd
2. Februar 2021 13:00 Uhr Lennart Weiß Wolfrum Group tbd
9. Februar 2021 13:00 Uhr Jonathan Rapp Gleich Group tbd