Speaker: MSc. Rouven Arnold - Doctoral student in the research group "Epigenetics of Skin Aging" led by Prof. Karima Djabali
Time: 5 November 2019, 1 pm
Place: Munich School of BioEngineering (Lecture Hall E.126, Boltzmannstr. 11, 85748 Garching)
Abstract: Hutchinson-Gilford progeria syndrome (HGPS), a rare premature aging disorder that leads to death at an average age of 14.7 years due to myocardial infarction or stroke, is caused by mutations in the LMNA gene. Triggered by the mutation, a harmful protein 'progerin' accumulates in the patients' cell nuclei. Children suffering from HGPS develop numerous clinical features that overlap with normal aging. This talk will focus on our latest research using text mining to identify signaling pathway(s) underlying HGPS.