Titel: Engineering Interleukin 12 Family Cytokines
Sprecherin: Isabel Aschenbrenner (Feige Group)
Datum und Uhrzeit: Dienstag, 18. Juli 2023, 13:00 Uhr
Abstract: Interleukins (ILs) are secreted by immune cells and bound by their specific receptors on target cells to elicit their downstream regulatory functions. These include controlling the development, expansion, activation, and inactivation of immune cells as well as regulating pro- versus anti-inflammatory responses. Human IL-12 family cytokines regulate immune responses and are emerging therapeutic targets. Nature uses assembly-dependent folding and subunit sharing within this family, making their cellular biogenesis highly complex. Based on our broadened understanding of IL-12 family cytokine biogenesis on a structural, mechanistic, and cellular level, we now aim to rationally design human ILs. We follow novel approaches to control secretion and function of specific IL-12 family members for therapeutic modulations of the human immune response.
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Dies ist der letzte Vortrag im Sommersemester 2023.
Das MIBE Seminar startet wieder im Oktober 2023 mit neuen Vorträgen aus den Forschungsgruppen.