Title: Modelling liver complexity with organoids
Speaker: Prof. Anna Dowbaj (Dowbaj Group)
Date and Time: Tuesday 08 July 2025, 13:00
Abstract: Organoids are 3D structures grown from stem cells embedded in extracellular matrix, and consisting of organ-specific cell types that self-organize into one structure. For the liver, the epithelial cell organoids from adult tissue hepatocytes or cholangiocytes have been derived, but they lacked cell complexity and the stem cell niche – supporting cells from immune, endothelium and mesenchymal compartments. We developed next-generation organoid models, which incorporate one of the previously missing components – the mesenchymal cells. Organoids containing more cell types led to better recapitulation of complex liver architecture in a dish, which now allow more precise modelling of homeostasis and liver disease in vitro. The most recent study has recently been published in Nature: https://www.nature.com/articles/s41586-025-09183-9.
More information
The MIBE Seminar will take place in our lecture hall E.126 (Boltzmannstr. 11, 85748 Garching) and will be live streamed via zoom.
The zoom details for all online seminar talks this semester are:
Meeting Name: MIBE Seminar Talks, Tuesdays 1:00 pm
https://tum-conf.zoom.us/j/69851298624?pwd=TURFMGQ5N3pDZ0ZGVkVHejFTMFJhUT09
Meeting-ID: 698 5129 8624
Password: mibe
The MIBE Seminar counts as subject specific qualification for doctoral candidates.
Register here.
Further Program SUMMER TERM 2025
The seminar series is being continued in the summer term 2025, further talks will be published here soon.