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MIBE Seminar: CANCELLED - Parahydrogen-Polarized [1-13C]Pyruvate for Reliable and Fast Preclinical Metabolic Magnetic Resonance Imaging

Topic: Parahydrogen-Polarized [1-13C]Pyruvate for Reliable and Fast Preclinical Metabolic Magnetic Resonance Imaging

Speaker: Wolfgang Gottwald

Date and Time: Tuesday 4 June 2024, 1:00 pm

Abstract: Hyperpolarization techniques increase nuclear spin polarization by more than four orders of magnitude, enabling metabolic MRI. Even though hyperpolarization has shown clear value in clinical studies, the complexity, cost and slowness of current equipment limits its widespread use. Here, a polarization procedure of [1-13C]pyruvate based on parahydrogen-induced polarization by side-arm hydrogenation (PHIP-SAH) in an automated polarizer is demonstrated. It is benchmarked in a study with 48 animals against a commercial dissolution dynamic nuclear polarization (d-DNP) device. Purified, concentrated (≈70–160 mM) and highly hyperpolarized (≈18%) solutions of pyruvate are obtained at physiological pH for volumes up to 2 mL within 85 s in an automated process. The safety profile, image quality, as well as the quantitative perfusion and lactate-to-pyruvate ratios, are equivalent for PHIP and d-DNP, rendering PHIP a viable alternative to established hyperpolarization techniques.

More information

The MIBE Seminar will take place in our lecture hall E.126 (Boltzmannstr. 11, 85748 Garching) and will be live streamed via zoom.

The zoom details for all online seminar talks this semester are:

Meeting Name: MIBE Seminar Talks, Tuesdays 1:00 pm
Meeting-ID: 698 5129 8624
Password: mibe

The MIBE Seminar counts as subject specific qualification for doctoral candidates.
Registration here.

Further Program SUMMER TERM 2024

Jun 18, 2024    Henriette Bast             Pfeiffer Group             Clinical Dark-Field Radiography of Human Lungs

Jun 25, 2024    Dominik John              Herzen Group             From Images to Insights: Quantitative Phase-
                                                                                                Contrast Imaging for the Analysis of Biomedical
                                                                                                Specimens and Materials at a Synchrotron Source

Jul 09, 2024     Francesca Gasparin   Ntziachristos Group     Optoacoustic Microscopy
                         & Ludwig Englert