MSB Online Seminar: Wide Angle Xray Scattering (WAXS) on Kidney Stones at the MuCLS

Titel: Wide Angle Xray Scattering (WAXS) on Kidney Stones at the MuCLS

Datum und Uhrzeit: Dienstag, 08. Dezember 2020, 13:00 Uhr

Sprecherin:  Johannes Melcher, Arbeitsgruppe „Phase-contrast x-ray imaging” (Prof. Franz Pfeiffer)

Abstract:
Once kidney stones grow to a large extent, they often cause contraction like pain and a ureteral colic. The treatment of kidney stones heavily depends on their type or -in other words- their composition.
Standard examination tools are chemical analysis of the urine orif the stone is removed infrared spectroscopy, for example. [1] Since the kidney filters superfluous concentration of minerals from the blood, calcium oxalate or uric acid can accumulate in these organs and crystallise to kidney stones. Such crystalline structures can be investigated using X-ray diffractometry as well.
Since X-ray diffractometry requires a quasi-monochromatic X-ray spectrum, data acquisition takes very long at laboratory diffractometers based on X-ray tubes. This issue is overcome by brilliant X-rays provided by inverse Compton X-ray facilities, such as the Munich Compact Light Source (MuCLS). Consequently, we have been developing an wide angle X-ray scattering (WAXS) setup at the MuCLS for the classification of kidney stones.
In this progress report, the WAXS setup installed at the MuCLS and its characterisation are presented. Following these initial measures, the sensitivity of this setup for the classification of kidney stones is evaluated, first, by measuring the pure components of the different types of kidney stones and, second, on individual kidney stones. Finally, the ability to determine kidney stones in the presence of tissue, i.e. the kidney itself, has been investigated.
[1] Gerd Herold, Innere Medizin 2017 Page 654