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MIBE Seminar: Scalable Tissue Clearing Technologies for Unbiased Study of Entire Organs and Organisms

Topic: Scalable Tissue Clearing Technologies for Unbiased Study of Entire Organs and Organisms

Speaker: Jennifer Modamio (Hebrok Group)

Date and Time: Tuesday 14 May 2024, 1:00 pm

Abstract: Recent breakthroughs in tissue-clearing methodologies have transformed the study of intact tissues, organs, and organisms, offering a 3D visualization of interconnected systems at a single-cell resolution. These methods, integrated with light-sheet microscopy, AI-based analysis, and proteomics, streamline histological and molecular examinations, potentially reducing processing time and cost. The chemical processes enable whole-organ labeling, broadening the scope to include thick human tissues and facilitating comprehensive whole-body scanning of small mammalian models. By harnessing this synergy, researchers can rapidly extract comprehensive, multiscale insights from complex biological specimens. This seminar will provide an overview of cutting-edge tissue-clearing approaches, emphasizing the versatile DISCO protocols. Common implementation challenges and solutions will be addressed to equip attendees with the necessary knowledge to adopt these technologies seamlessly. Participants will gain valuable insights into using these technologies for unbiased, systems-level investigations spanning entire organs and organisms for an unprecedented understanding of biological processes to support disease research.

More information

The MIBE Seminar will take place in our lecture hall E.126 (Boltzmannstr. 11, 85748 Garching) and will be live streamed via zoom.

The zoom details for all online seminar talks this semester are:

Meeting Name: MIBE Seminar Talks, Tuesdays 1:00 pm
Meeting-ID: 698 5129 8624
Password: mibe

The MIBE Seminar counts as subject specific qualification for doctoral candidates.
Registration here.

Further Program SUMMER TERM 2024

May 28, 2024   Filipa Goncalves        Westmeyer Group       Title tbd

Jun 11, 2024    Florian Schaff             Pfeiffer Group             Title tbd

Jun 18, 2024    Henriette Bast             Pfeiffer Group             Title tbd

Jun 25, 2024    Dominik John              Herzen Group             Title tbd

Jul 09, 2024     Francesca Gasparin   Ntziachristos Group     Optoacoustic Microscopy
                        Ludwig Englert