News Organoids & Disease Model Systems

12 December 2024 | Whether it's type 1 diabetes, other autoimmune diseases or organ transplants – when the immune system gets out of balance, it can be dangerous. Instead of suppressing the entire system as a consequence and risking severe side effects, it would be preferable to regulate it in a targeted and localized manner. This is precisely what researchers have now engineered regulatory immune cells for.

11 December 2024 | A team led by researchers at TUM has, for the first time, grown tumor organoids that mimic the different structures and characteristics of pancreatic cancer. The scientists investigated how the various tumor organoids react to established and novel treatments. This opens the door to the development of effective new therapies.

29 February 2024 | Children with Hutchinson-Gilford Progeria Syndrome develop premature aging symptoms. Prof. Karima Djabali wants to understand the biological mechanisms behind these accelerated aging processes.

1 June 2023 | In this issue of "NewIn," we introduce Matthias Hebrok. The professor of Applied Stem Cell and Organoid Systems and director of the new TUM Center for Organoid Systems creates organ-like structures from stem cells.

4 April 2023 | The biologist and medical researcher Matthias Hebrok is being awarded a Bavarian Distinguished Professorship.

13 July 2021 | In addition to chemical factors, mechanical influences play an important role in the natural growth of human organs – but also in the development of tumors. Now a research team at the Technical University of Munich (TUM) has investigated the process in detail using organoids, three-dimensional model systems of organs which are produced in the laboratory.

26 September 2019 | Cellular control proteins, referred to as chaperones, detect immature immune signaling proteins and prevent them from leaving the cell.

09 September 2019 | Faszination Forschung – the science magazine of the Technical University of Munich (TUM) – reported on the work at the Bavarian NMR Center (BNMRZ) at TUM. 

27 August 2019 | Researchers at TUM and the Helmholtz Zentrum München have moved a step closer towards developing innovative drug molecules for the treatment of psychiatric diseases. They discovered how inhibitors inactivate a special protein that plays a key role in various diseases. Their approach can be applied to other medically relevant proteins where the development of specific inhibitors has proved difficult up to now. The research effort was led by Michael Sattler, Director of the Institute of Structural Biology at the Helmholtz Zentrum München and Professor of Biomolecular NMR-Spectroscopy at TUM as well as Principal Investigator at the MSB.