News Organoids & Disease Model Systems

  • Nuclei of HGPS cells

    Understanding the mechanisms of premature aging in progeria

    “Can we delay age-related diseases?”

    29 February 2024 | Children with Hutchinson-Gilford Progeria Syndrome develop premature aging symptoms. Prof. Karima Djabali wants to understand the biological mechanisms behind these accelerated aging processes.

  • NewIn: Matthias Hebrok.

    NewIn: Matthias Hebrok

    Researching diabetes and pancreatic cancer with miniature organs

    1 June 2023 | In this issue of "NewIn," we introduce Matthias Hebrok. The professor of Applied Stem Cell and Organoid Systems and director of the new TUM Center for Organoid Systems creates organ-like structures from stem cells.

  • First author Benedikt Buchmann at the microscope. Through time-resolved observation of the cells, the research team was able to investigate the interactions between the organoid cells and the surrounding collagen in detail. Image: M. Kratzer / TUM

    Organoids help understand the complex interactions of cells and tissue

    Mechanical stimuli influence organ growth

    13 July 2021 | In addition to chemical factors, mechanical influences play an important role in the natural growth of human organs – but also in the development of tumors. Now a research team at the Technical University of Munich (TUM) has investigated the process in detail using organoids, three-dimensional model systems of organs which are produced in the laboratory.

  • Abraham Lopez, Matthias Feige, Michael Sattler,  and Sina Bohnacker (from left).  Image: A. Heddergott / TUM

    Quality control in immune communication

    26 September 2019 | Cellular control proteins, referred to as chaperones, detect immature immune signaling proteins and prevent them from leaving the cell.

  • Michael Sattler at the BNMRZ.

    How proteins work – Article in TUM’s science magazine

    09 September 2019 | Faszination Forschung – the science magazine of the Technical University of Munich (TUM) – reported on the work at the Bavarian NMR Center (BNMRZ) at TUM. 

  • Mechanism of new small molecule inhibitors for the treatment of depression, pain and obesity decoded

    27 August 2019 | Researchers at TUM and the Helmholtz Zentrum München have moved a step closer towards developing innovative drug molecules for the treatment of psychiatric diseases. They discovered how inhibitors inactivate a special protein that plays a key role in various diseases. Their approach can be applied to other medically relevant proteins where the development of specific inhibitors has proved difficult up to now. The research effort was led by Michael Sattler, Director of the Institute of Structural Biology at the Helmholtz Zentrum München and Professor of Biomolecular NMR-Spectroscopy at TUM as well as Principal Investigator at the MSB.